馬 徹
研究重點為傳染病及癌症新藥研發，利用結構生物學的技術（X光結晶學，低溫電子顯微鏡）探討抗藥性細菌感染，流感與癌細胞之膜蛋白及醣蛋白結構，作為新藥研發的基礎。
1，藉由分析蛋白質的立體空間結構，作為新藥設計的基礎。
2，運用細胞及動物實驗模型，探討新型藥物之廣度及效能。
EDUCATION AND POSITIONS HELD:
- B.S., Chemistry, National Taiwan University, 1992
- M.S., Chemistry, University of Pennsylvania, 1996
- Ph.D., Chemistry, University of Pennsylvania, 2000
- Postdoctoral Fellow, University of California at San Diego, 2001
- Postdoctoral Fellow, The Scripps Research Institute, 2001–2004
- Assistant Professor, Genomics Research Center, Academia Sinica, Taiwan, 2004-2010
- Associate Professor, Genomics Research Center, Academia Sinica, Taiwan, 2010-2019
- Visiting Scientist, RIKEN SPring-8 Center, Japan, 2016 – present
- Division Director of Chemical Biology, GRC, Academia Sinica, Taiwan, 2016 – present
- Professor, Genomics Research Center, Academia Sinica, Taiwan, 2019-present
RESEARCH INTERESTS:
Structure of membrane proteins in drug discovery
The research focus of our laboratory is to study the structure and function of membrane proteins, and to understand their relationships in human diseases. Major efforts have been made over the last few years into the two topics in infectious diseases. First, in order to overcome the problems of drug-resistant bacterial infection, a new enzyme target for antibiotic development, the membrane-bound bifunctional transglycosylase, has been chosen for structural and functional analysis. We have successfully determined the X-ray crystal structure of this membrane-bound enzyme in complex with its inhibitor moenomycin, and studied its mechanism of peptidoglycan synthesis. In addition, a high-throughput screening method for finding new antibiotics has been developed using the purified full-length membrane protein. In parallel, structure-based drug design with our crystal structure is ongoing. Second, we have studied the effect of glycosylation on influenza virus major surface protein hemagglutinin (HA) with regards to its role in receptor binding and immune response, and developed a new strategy for molecular vaccine design.
膜蛋白結構生物學與新藥研發
我們的研究重點是使用x光結晶學以及核磁共振光譜學來探討膜蛋白的結構。膜蛋白是使細胞能夠正常運作的重要組成之一，它們負責細胞內外像是離子傳導、分子傳輸、以及訊息接受等等的重要工作。膜蛋白的正常運作對於我們的健康非常重要，異常的膜蛋白與許多嚴重疾病有密切的關係。我們希望運用x光結晶學來決定具有醫療重要性的膜蛋白之結構。核磁共振光譜學將有助於針對這些結構的新藥開發。
RESEARCH HIGHLIGHTS:
- 2008/01/14, 新突破方法開發新抗生素
- 2009/05/21, 馬徹實驗室發表細菌膜蛋白酵素完整結構，尋找新型抗生素有譜
- 2009/08/25, 細菌膜蛋白酵素完整結構研究備受矚目
- 2009/10/11, 流感病毒的感染以及疫苗設計的關鍵，都在於『醣』的多寡！
- 2009/10/15, 馬徹助研究員獲選為TWAS年輕學者
HONORS:
- University of Pennsylvania, Teaching Assistant Award, 1995
- Keystone Symposia Scholarship, Frontiers of Structural Biology, 2003
- The Skaggs Postdoctoral Fellowship, 2001–2003
- TWAS Young Affiliate, 2009-2013
- Academia Sinica Significant Research Achievements, 2009
- Academia Sinica Research Award for Junior Research Investigators, 2010
- Two research highlights in Taiwan Yearbook of Technology, 2010
- The Young Scholar Award of Tien-De Li Biomedical Foundation, 2011
- Academia Sinica Significant Research, 2012
- Academia Sinica Career Development Award, 2013
- Exceptional Merit in Academic Award from Chung Hwa Rotary Educational Foundation, 2014
- Taiwan Bio-Development Foundation Chair in Biotechnology, 2014